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Active delivery of Zinc Fingers for in vivo enhancement of gene regulation

A universal method to enhance control of gene expression in vivo with artificial gene-regulatory transcription factors.

Zinc finger therapy for Fragile X-Associated Tremor/Ataxia Syndrome (FXTAS)

New zinc finger peptides and encoding nucleic acid molecules that can be used for the modulation of gene expression; this has therapeutic applications for neuro-degenerative disorders like FXTAS where altered expression of genes is part of the disease aetiology.

Zinc finger therapy for Amyotrophic lateral sclerosis (ALS) and Frontotemporal dementia (FTD)

New zinc finger peptides and encoding nucleic acid molecules that can be used for the modulation of gene expression in vitro and/or in vivo. This invention has therapeutic applications for neurological disorders such as ALS and FTD where altered expression of genes is part of the disease aetiology.

Charcot-Marie Tooth Disease model

Model for Charcot-Marie Tooth Disease

MicroRNA Biomarkers for ectopic or intrauterine pregnancy

MicroRNA are important gene regulators and their expression profiles change with pathophysiology, allowing their use as biomarkers. Imperial researchers have identified differential markers that can distinguish pregnancy of unknown location (PUL).

New handwashing solution to prevent spread of infectious diseases

This innovative technology proposes a new solution that improves handwashing practice and could help to prevent the spread of infectious diseases such as COVID-19, cholera and diarrhoea-related issues due to poor hygiene, especially in developing countries.

Transcutaneous fluorescence spectroscopy to assess gut permeability and gastric emptying rate

The present invention relates to a device and methods for non-invasive measurement of gut permeability and gastric empyting rate.

Self-disinfecting appliances

A novel device that can be fitted to home-care appliances to generate hydrogen peroxide or bleach, effectively producing a ‘self-cleaning’ appliance.

A novel dimer system for single small molecule detection

A new method for the efficient and accurate detection of proteins with nanopores by utilising aptamer-modified gold nanoparticle (AuNP) dimer carriers.

Hybrid nanopore opto-electronic platform for single molecule biological screening

A molecular beacon-modified DNA carrier to specifically identify short nucleic acids and small proteins using a synchronised opto-electronic platform with nanopipette.

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